This is a onboard exim possibility to blacklist special addresses, its only a optional file which contains a list of envelope senders whose messages will be denied;
550-sender envelope address firstname.lastname@example.org is locally blacklisted here
Example of content:
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cat /etc/exim4/local_sender_blacklist email@example.com firstname.lastname@example.org
Restart or reload of exim is not required.
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